Moderna booster shot increases antibody levels against Omicron, company says

Biotechnology company Moderna announced Monday that preliminary data suggests its half-dose booster shot increased antibody levels against the Omicron coronavirus variant -- and a larger-sized dose of the booster increases antibody levels even more. Currently, Moderna's booster is administered as a 50-microgram dose. The company announcement noted that this dose increased antibody levels 37-fold, compared with the levels seen when a fully vaccinated person does not receive a booster, and a 100-microgram dose increased antibody levels 83-fold.
It remains unclear what these increases mean as far as how well the booster doses clinically work against Omicron. But in the company's statement, CEO Stéphane Bancel called the data reassuring. "The dramatic increase in COVID-19 cases from the Omicron variant is concerning to all. However, these data showing that the currently authorized Moderna COVID-19 booster can boost neutralizing antibody levels 37-fold higher than pre-boost levels are reassuring," Bancel said.
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